Synthesis and Bological Activity of Novel Imidazoles

Abstract

N-phenylglycine (l) undergoes facile cyclocondensation with benzaldehydes to gives the corresponding 4- benzylidene-2-phenyloxazol-5-one (2) in good yields. The 4-benzylidene-2-phenyloxazol-5-one (2) condensed with 2-amino substituted benzothiazole (3a-f) afforded 4- benzyl idene-1-(substitued-2-benzothiazolyl)-2-phenyl1H-imidazol-5( 4H)-one (4a-f). The structures of these compounds were recognized because of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.