Formulation and Evaluation of Fast Dissolving Tablets (Fdts) of Cefpodoxime Proxetil

Abstract

The present study was done to fonnulate fast dissolving tablets of cefpodoxime proxetil for enhanced solubility and dissolution profile. In our study various batches (Cp 1- 9) were fonnulated with different ratios of superdisintegrants viz, sodium starch glycolate and microcrystalline cellulose in combination with croscarmellose sodium (1 .6%, 3.2%, 4.8%). Aspartame as sweetening agent and flavour was added to increase the patient compliance. Pre-compression parameters including angle ofrepose, densities, compressibility were evaluated. The prepared tablets were evaluated for hardness, friability, weight variation, disintegration time, in vitro dispersion time and in vitro drug release studies. In our study on the basis of evaluation parameters, batch Cp8 was best formulation . In vitro dissolution studies shows more than 60% of the drug released within 5 minutes.